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Article

Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.

PloS one - 23 Jul 2008

Banerjee Rebecca, Mosley R Lee, Reynolds Ashley D, Dhar Alok, Jackson-Lewis Vernice, Gordon Paul H, Przedborski Serge, Gendelman Howard E

Abstract excerpt

BACKGROUND: Innate neuroimmune dysfunction is a pathobiological feature of amyotrophic lateral sclerosis (ALS). However, links, if any, between disease and adaptive immunity are poorly understood. Thus, the role of T cell immunity in disease was investigated in human G93A superoxide dismutase 1 (SOD1) transgenic (Tg) mice and subsequently in ALS patients. METHODS AND FINDINGS: Quantitative and qualitative immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18648532
DOI: 10.1371/journal.pone.0002740
PMCID: PMC2481277

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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