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Article

Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain.

Cell - 8 Feb 1991

Farnsworth C L, Marshall M S, Gibbs J B, Stacey D W, Feig L A

Abstract excerpt

The double mutation, D33H/P34S, reduced the transforming activity of oncogenic RasH proteins, G12V and Q61L, 400- and 20-fold, respectively. Remarkably, this same mutation did not reduce the transforming activity of normal RasH, nor did it impair the ability of the protein to restore a functional Ras pathway in cells whose endogenous Ras proteins were inhibited. Another mutation in this region, D38N, had similar...

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Identifiers

PMID: 1899358
DOI: 10.1016/0092-8674(91)90246-u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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