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Article

Activating mutation of adenylyl cyclase reverses its inhibition by G proteins.

Molecular pharmacology - 1 Nov 1999

Zimmermann G, Zhou D, Taussig R

Abstract excerpt

We have implemented a yeast genetic selection developed previously by our laboratory to identify mutant mammalian type V adenylyl cyclases insensitive to inhibition by G(ialpha.) One mutation isolated was localized to the first cytoplasmic domain at a Phe residue (position 400), which is conserved in all nine isoforms of membrane-bound mammalian adenylyl cyclase. Biochemical characterization of the F400Y mutant...

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PMID: 10531392
DOI: 10.1124/mol.56.5.895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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