Activating mutation of adenylyl cyclase reverses its inhibition by G proteins.

doi:10.1124/mol.56.5.895

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Article

Activating mutation of adenylyl cyclase reverses its inhibition by G proteins.

Molecular pharmacology - 1 Nov 1999

Zimmermann G, Zhou D, Taussig R

Abstract excerpt

We have implemented a yeast genetic selection developed previously by our laboratory to identify mutant mammalian type V adenylyl cyclases insensitive to inhibition by G(ialpha.) One mutation isolated was localized to the first cytoplasmic domain at a Phe residue (position 400), which is conserved in all nine isoforms of membrane-bound mammalian adenylyl cyclase. Biochemical characterization of the F400Y mutant...

Topics

Adenylyl Cyclase Inhibitors
Adenylyl Cyclases
Enzyme Activation
Enzyme Inhibitors
GTP-Binding Proteins
Models, Molecular
Mutation
Saccharomyces cerevisiae

Source

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Identifiers

PMID: 10531392
DOI: 10.1124/mol.56.5.895

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