Article
Distinct resistance mutation and polymorphism acquisition in HIV-1 protease of subtypes B and F1 from children and adult patients under virological failure.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2009
Dumans Ana T, Barreto Cláudia C, Santos André F, Arruda Mônica, Sousa Thatiana M, Machado Elizabeth S, Sabino Ester C, Brindeiro Rodrigo M, Tanuri Amílcar, Duarte Alberto J, Soares Marcelo A
Abstract excerpt
The goal of this work was to compare the differences between human immunodeficiency virus type 1 (HIV-1) of B and F1 subtypes in the acquisition of major and minor protease inhibitor (PI)-associated resistance mutations and of other polymorphisms at the protease (PR) gene, through a cross sectional study. PR sequences from subtypes B and F1 isolates matched according to PI exposure time from Brazilian patients...
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