Article
Drug resistance mutation profile and accumulation kinetics in human immunodeficiency virus-positive individuals infected with subtypes B and F failing highly active antiretroviral therapy are influenced by different viral codon usage patterns.
Antimicrobial agents and chemotherapy - 1 Dec 2008
Waléria-Aleixo A, Martins A N, Arruda M B, Brindeiro R M, Da-Silva R M, Nobre F F, Greco D B, Tanuri A
Abstract excerpt
The major human immunodeficiency virus type 1 subtype circulating in Brazil is B, followed by F and C. We have genotyped 882 samples from Brazilian patients for whom highly active antiretroviral therapy failed, and we found subtype B and the unique recombinant B/F1 forms circulating. Due to codon usage variation, there is a significantly lower incidence of the substitutions L210W, Q151M, and F116Y in subtype F1...
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