Article
Genetic variation and susceptibilities to protease inhibitors among subtype B and F isolates in Brazil.
Antimicrobial agents and chemotherapy - 1 Feb 1999
Tanuri A, Vicente A C, Otsuki K, Ramos C A, Ferreira O C, Schechter M, Janini L M, Pieniazek D, Rayfield M A
Abstract excerpt
The genetic variation of the human immunodeficiency virus type 1 (HIV-1) protease gene (prt) permits the classification of HIV-1 strains into five distinct protease subtypes, which follow the gag subtyping patterns. The susceptibilities of non-B-subtype strains to protease inhibitors (PIs) and other antiretroviral drugs remain largely unknown. Subtype F is the main non-B strain contributing to the Brazilian...
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