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Article

No evidence of the APC D1822V missense variant's pathogenicity in Tunisian patients with sporadic colorectal cancer.

Pathologie-biologie - 1 May 2009

Bougatef K, Marrakchi R, Ouerhani S, Sassi R, Moussa A, Kourda N, Blondeau Lahely Y, Najjar T, Ben Jilani S, Soubrier F, Ben Ammar Elgaaied A

Abstract excerpt

OBJECTIVES: Sporadic colorectal cancer is influenced by numerous single nucleotide polymorphisms (SNPs), each with minor effects on the cancer risk. This study seeks to determine whether there is any association of the I1307K, E1317Q and D1822V variants within the Adenomatous polyposis coli gene (APC) and risk to develop colorectal cancer in Tunisian population. METHODS: Direct sequencing was used to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18343606
DOI: 10.1016/j.patbio.2008.01.004

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APC

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