Article
Experimental models of lupus nephritis.
Contributions to nephrology - 1 Jan 2011
Grande Joseph P
Abstract excerpt
A number of murine models recapitulate many of the features of systemic lupus. Spontaneous models of lupus have provided the basis for genetic linkage studies to define loci that confer an increased risk of nephritis in susceptible mice. Functional relevance of genes within susceptibility loci have been verified through the use of transgenic mice bearing targeted deletions or overexpression of candidate genes....
Topics
- Animals
- Autoantibodies
- B-Lymphocytes
- Cytokines
- Disease Models, Animal
- Genetic Predisposition to Disease
- Humans
- Lupus Nephritis
- Mice
- Mice, Knockout
- T-Lymphocytes