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Microarray Analysis of Glomerular Gene Expression in Murine Lupus Nephritis

1 Jan 2008

Abstract excerpt

To elucidate the molecular mechanism of glomerular events in lupus nephritis, we performed genome-wide mRNA expression analysis of glomeruli microdissected from lupus mice. MRL/lpr mice (12-week-old) were orally given vehicle or prednisolone (10 mg/kg per day) for 4 weeks. Renal histology of MRL/lpr mice revealed mesangial proliferative glomerulonephritis with cellular infiltration of macrophages, T cells, and...

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PMID: 18187931
DOI: 10.1254/jphs.fp0071337

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