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Molecular mechanisms governing the progression of nephritis in lupus prone mice and human lupus patients

28 Feb 2023

Abstract excerpt

Introduction: Pathologic inflammation is a major driver of kidney damage in lupus nephritis (LN), but the immune mechanisms of disease progression and risk factors for end organ damage are poorly understood. Methods: To characterize molecular profiles through the development of LN, we carried out gene expression analysis of microdissected kidneys from lupus-prone NZM2328 mice. We examined male mice and the...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 36936908
DOI: 10.3389/fimmu.2023.1147526

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