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Article

Insulin-Induced Gene 2 Involvement in Human Adipocyte Metabolism and Body Weight Regulation

5 Mar 2008

Abstract excerpt

BACKGROUND: Insulin-induced genes (INSIGs) encode proteins that block proteolytic activation of sterol regulatory element-binding proteins, transcription factors that regulate lipogenic enzymes, and adipocyte differentiation. OBJECTIVE: Here, we analyzed the relative significance of INSIG1 and INSIG2 in human liver and adipocyte metabolism, and defined a novel, functional polymorphism in the promoter of INSIG2...

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Identifiers

PMID: 18319320
DOI: 10.1210/jc.2007-1850

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Insulin-Induced Gene 2 Involvement in Human Adipocyte Metabolism and Body Weight RegulationPMID 18319320Read ↗

INSIG1 influences obesity-related hypertriglyceridemia in humans.Semantic proximity Read ↗

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Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels.Semantic proximity Read ↗

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Common INSIG2 polymorphisms are associated with age-related changes in body size and high-density lipoprotein cholesterol from young adulthood to middle age.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

Association of INSIG2 polymorphism with overweight and LDL in children.Semantic proximity Read ↗

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.Semantic proximity Read ↗

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The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.Semantic proximity Read ↗

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