Article

Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line

2025-05-21

Abstract excerpt

<h4>Summary</h4> Transgenic mouse strains are essential tools in neuroscience, enabling targeted genetic manipulations to investigate brain function and neurological diseases. The NEX-Cre mouse line, which targets glutamatergic principal neurons in the neocortex and hippocampus by expressing Cre-recombinase under the NEX (NeuroD6) promotor, has been widely used for conditional gene manipulation. Contrary to previ...

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Literature Corpus work: 05438610-0831-512b-9870-07dd0c6858ba
DOI: 10.1101/2025.05.21.655260

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