Article
Animal models and therapeutic prospects for Charcot-Marie-Tooth disease.
Annals of neurology - 1 Sept 2013
Bouhy Delphine, Timmerman Vincent
Abstract excerpt
Charcot-Marie-Tooth (CMT) neuropathies are inherited neuromuscular disorders caused by a length-dependent neurodegeneration of peripheral nerves. More than 900 mutations in 60 different genes are causative of the neuropathy. Despite significant progress in therapeutic strategies, the disease remains incurable. The increasing number of genes linked to the disease, and their considerable clinical and genetic...
Topics
- Animals
- Animals, Genetically Modified
- Charcot-Marie-Tooth Disease
- Disease Models, Animal
- Humans
- Mutation