Article
SHIRPA, a protocol for behavioral assessment: validation for longitudinal study of neurological dysfunction in mice.
Neuroscience letters - 22 Jun 2001
Rogers D C, Peters J, Martin J E, Ball S, Nicholson S J, Witherden A S, Hafezparast M, Latcham J, Robinson T L, Quilter C A, Fisher E M
Abstract excerpt
Mouse models of neurological abnormalities are only valuable if accurately assessed. The three-stage SHIRPA procedure is used for the standardised assessment of mouse phenotype and has been reported in a high throughput experiment in which different mutants were ascertained at one age point using stage 1 of the protocol. In this study we have validated SHIRPA using a large cohort with one single mutation, 'legs...
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