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Article

Uncovering Hidden Phenotypes in NEX-Cre Mice: Behavioral and Cellular Alterations Demand Re-Evaluation of a Widely Used Transgenic Line.

Journal of neurochemistry - 1 Mar 2026

Renken Kim, Masseck Olivia Andrea

Abstract excerpt

Transgenic mouse strains are essential tools in neuroscience, enabling targeted genetic manipulations to investigate brain function and neurological diseases. The NEX-Cre mouse line, which targets glutamatergic principal neurons in the neocortex and hippocampus by expressing Cre-recombinase under the NEX (NeuroD6) promoter, has been widely used for conditional gene manipulation. Contrary to previous reports...

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PMID: 41833530
DOI: 10.1111/jnc.70401
PMCID: PMC12989317

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CA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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