Article
Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.
PLoS genetics - 1 Oct 2008
Davuluri Gangarao, Gong Weilong, Yusuff Shamila, Lorent Kristin, Muthumani Manimegalai, Dolan Amy C, Pack Michael
Abstract excerpt
The recessive lethal mutation flotte lotte (flo) disrupts development of the zebrafish digestive system and other tissues. We show that flo encodes the ortholog of Mel-28/Elys, a highly conserved gene that has been shown to be required for nuclear integrity in worms and nuclear pore complex (NPC) assembly in amphibian and mammalian cells. Maternal elys expression sustains zebrafish flo mutants to larval stages...
Topics
- Amino Acid Sequence
- Animals
- Apoptosis
- Cell Cycle
- Checkpoint Kinase 2
- DNA Damage
- DNA Replication
- Genes, p53
- Intestinal Mucosa
- Intestines
- Molecular Sequence Data
- Mutation
- Nuclear Pore Complex Proteins
- Protein Serine-Threonine Kinases