Article
Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.
Gastroenterology - 1 Mar 2009
de Jong-Curtain Tanya A, Parslow Adam C, Trotter Andrew J, Hall Nathan E, Verkade Heather, Tabone Tania, Christie Elizabeth L, Crowhurst Meredith O, Layton Judith E, Shepherd Iain T, Nixon Susan J, Parton Robert G, Zon Leonard I, Stainier Didier Y R, Lieschke Graham J, Heath Joan K
Abstract excerpt
BACKGROUND & AIMS: Zebrafish mutants generated by ethylnitrosourea-mutagenesis provide a powerful tool for dissecting the genetic regulation of developmental processes, including organogenesis. One zebrafish mutant, "flotte lotte" (flo), displays striking defects in intestinal, liver, pancreas, and eye formation at 78 hours postfertilization (hpf). In this study, we sought to identify the underlying mutated gene...
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