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Article

Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.

PloS one - 1 Jan 2012

Robu Mara E, Zhang Yong, Rhodes Jennifer

Abstract excerpt

Disruption of early mitotic inhibitor 1 (Emi1) interferes with normal cell cycle progression and results in early embryonic lethality in vertebrates. During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 protein, thereby enabling the accumulation of Cyclins A and B so they can regulate replication and promote the transition from G2 phase to mitosis, respectively. Depletion of Emi1...

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Identifiers

PMID: 23082190
DOI: 10.1371/journal.pone.0047658
PMCID: PMC3474755

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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