Article
Low-penetrance susceptibility variants in familial colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2010
Niittymäki Iina, Kaasinen Eevi, Tuupanen Sari, Karhu Auli, Järvinen Heikki, Mecklin Jukka-Pekka, Tomlinson Ian P M, Di Bernardo Maria Chiara, Houlston Richard S, Aaltonen Lauri A
Abstract excerpt
BACKGROUND: Genomewide association studies have identified 10 low-penetrance loci that confer modestly increased risk for colorectal cancer (CRC). Although they underlie a significant proportion of CRC in the general population, their impact on the familial risk for CRC has yet to be formally enumerated. The aim of this study was to examine the combined contribution of the 10 variants, rs6983267, rs4779584,...
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