Article
Eleven candidate susceptibility genes for common familial colorectal cancer.
PLoS genetics - 1 Jan 2013
Gylfe Alexandra E, Katainen Riku, Kondelin Johanna, Tanskanen Tomas, Cajuso Tatiana, Hänninen Ulrika, Taipale Jussi, Taipale Minna, Renkonen-Sinisalo Laura, Järvinen Heikki, Mecklin Jukka-Pekka, Kilpivaara Outi, Pitkänen Esa, Vahteristo Pia, Tuupanen Sari, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
Hereditary factors are presumed to play a role in one third of colorectal cancer (CRC) cases. However, in the majority of familial CRC cases the genetic basis of predisposition remains unexplained. This is particularly true for families with few affected individuals. To identify susceptibility genes for this common phenotype, we examined familial cases derived from a consecutive series of 1514 Finnish CRC...
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