Prion Strain Diversity.

doi:10.1101/cshperspect.a024349

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Article

Prion Strain Diversity.

Cold Spring Harbor perspectives in medicine - 1 Dec 2016

Bartz Jason C

Abstract excerpt

Prion diseases affect a wide range of mammal species and are caused by a misfolded self-propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions exist and are operationally defined by differences in a heritable phenotype under controlled experimental transmission conditions. Prion strains can differ in incubation period, clinical signs of disease, tissue tropism, and host range....

Topics

Animals
Brain
Cattle
Humans
Phenotype
PrPSc Proteins
Prion Diseases
Protein Conformation
Sheep
Species Specificity

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Identifiers

PMID: 27908925
DOI: 10.1101/cshperspect.a024349
PMCID: PMC5131755

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