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Article

Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy.

Journal of virology - 1 Dec 1994

Bessen R A, Marsh R F

Abstract excerpt

The molecular basis of strain variation in scrapie diseases is unknown. The only identified component of the agent is the posttranslationally modified host prion protein (PrPSc). The biochemical and physical properties of PrP from two strains of transmissible mink encephalopathy (TME), called hyper (HY) and drowsy (DY), were compared to investigate if PrP heterogeneity could account for strain diversity. The...

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Identifiers

PMID: 7966576
DOI: 10.1128/JVI.68.12.7859-7868.1994
PMCID: PMC237248

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