Article
A common intronic variant of CXCR3 is functionally associated with gene expression levels and the polymorphic immune cell responses to stimuli.
The Journal of allergy and clinical immunology - 1 Dec 2008
Choi Jung-Won, Park Choon-Sik, Hwang Minyoung, Nam Hye-Young, Chang Hun Soo, Park Seong Gyu, Han Bok-Ghee, Kimm Kuchan, Kim Hyung Lae, Oh Bermseok, Kim Yeonjung
Abstract excerpt
BACKGROUND: CXCR3 is a chemokine receptor that plays important roles in mediating chemotactic signals and modulating the activation of lymphocytes. We have previously conducted a case-control study by using a candidate gene approach to investigate the association of CXCR3 polymorphisms with the risk of asthma. Results from the epidemiologic study showed that a common nucleotide variant in the CXCR3 intron...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.