Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.

The Journal of allergy and clinical immunology - 1 Jul 2010

Wise Emma L, Bonner Kandace T, Williams Timothy J, Pease James E

Abstract excerpt

BACKGROUND: The chemokine receptor CCR3 orchestrates the migration of eosinophils, basophils, T(H)2 lymphocytes, and mast cells during the allergic response, with CCR3 blockade a potential means of therapeutic intervention. Non-synonymous single nucleotide polymorphisms (SNPs) within the ccr3 gene have previously been described, with little information regarding their effects on CCR3 function. OBJECTIVE: To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cell Membrane
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Golgi Apparatus

Share to Lysosomes

Share to Mutagenesis, Site-Directed

Share to Protein Transport

Source

Identifiers

PMID: 20541248
DOI: 10.1016/j.jaci.2010.04.015

Genes

CCR3
CCL11
CCR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane.PMID 20541248Read ↗

Alanine scanning mutagenesis of the chemokine receptor CCR3 reveals distinct extracellular residues involved in recognition of the eotaxin family of chemokines.Semantic proximity Read ↗

Modulation of chemoattractant receptor function by C-terminus interactionsSemantic proximity Read ↗

Linkage and haplotype analysis for chemokine receptors clustered on chromosome 3p21.3 and transmitted in family pedigrees with asthma and atopy.Semantic proximity Read ↗

A common intronic variant of CXCR3 is functionally associated with gene expression levels and the polymorphic immune cell responses to stimuli.Semantic proximity Read ↗

CX3CR1 polymorphisms are associated with atopy but not asthma in German children.Semantic proximity Read ↗

Identification and Partial Characterization of a Variant of Human CXCR3 Generated by Posttranscriptional Exon SkippingSemantic proximity Read ↗

Variant eotaxin: its effects on the asthma phenotype.Semantic proximity Read ↗

CDHR3 Asthma-Risk Genotype Affects Susceptibility of Airway Epithelium to Rhinovirus C InfectionsSemantic proximity Read ↗

New variations of human CC-chemokine receptors CCR3 and CCR4.Semantic proximity Read ↗

A new CX3 CR1 genotype with implications for HIV disease progression.Semantic proximity Read ↗

Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics.Semantic proximity Read ↗

Identification of receptor binding and activation determinants in the N-terminal and N-loop regions of the CC chemokine eotaxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.