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Article

Polymorphisms in CXCR3 ligands predict early CXCL9 recovery and severe chronic GVHD.

Blood cancer journal - 27 Feb 2021

Dai Hao, Rachakonda Sivaramakrishna P, Penack Olaf, Blau Igor W, Blau Olga, Radujkovic Aleksandar, Müller-Tidow Carsten, Dreger Peter, Kumar Rajiv, Luft Thomas

Abstract excerpt

Chronic graft-versus-host disease (cGVHD) is a major cause of mortality and morbidity after allogeneic stem cell transplantation (alloSCT). The individual risk of severe cGVHD remains difficult to predict and may involve CXCR3 ligands. This study investigated the role of single-nucleotide polymorphisms (SNPs) of CXCL4, CXCL9, CXCL10, and CXCL11, and their day +28 serum levels, in cGVHD pathogenesis. Eighteen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33640906
DOI: 10.1038/s41408-021-00434-2
PMCID: PMC7914250

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