Article
Genetic effect of CCR3 and IL5RA gene polymorphisms on eosinophilia in asthmatic patients.
The Journal of allergy and clinical immunology - 1 Nov 2007
Lee June-Hyuk, Chang Hun Soo, Kim Ji Hyun, Park Se-Min, Lee Yong Mok, Uh Soo Taek, Rhim Taiyoun, Chung Il Yup, Kim Yong-Hoon, Park Byung Lae, Park Choon-Sik, Shin Hyoung Doo
Abstract excerpt
BACKGROUND: Eosinophilic infiltration and peripheral blood eosinophilia in asthma require the cooperation of eosinophil-specific cytokines and chemokines and their receptors. OBJECTIVE: We investigated the association of polymorphisms in CCR3 and IL5RA with asthma susceptibility or peripheral blood eosinophilia and the effects of the polymorphisms on receptor expression. METHODS: Polymorphisms in CCR3 and IL5RA...
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