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Article

Effects of human PrPSc type and PRNP genotype in an in-vitro conversion assay.

Neuroreport - 3 Dec 2008

Jones Michael, Peden Alexander H, Wight Darren, Prowse Christopher, Macgregor Ian, Manson Jean, Turner Marc, Ironside James W, Head Mark W

Abstract excerpt

Prion protein type and codon 129 genotype are thought to be major determinants of susceptibility and phenotype in human prion diseases. Using an in-vitro system (protein misfolding cyclic amplification) we have attempted to model human prion protein conversion using the abnormal prion protein associated with each of the major sporadic Creutzfeldt-Jakob disease subtypes, in substrates containing the normal...

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Identifiers

PMID: 18955905
DOI: 10.1097/WNR.0b013e328318edfa

Genes

PRNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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