Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role for CHIP in the aggresome pathway.

Molecular and cellular biology - 1 Jan 2009

Sha Youbao, Pandit Lavannya, Zeng Shenyan, Eissa N Tony

Abstract excerpt

Recent evidence suggests that aggresome formation is a physiologic stress response not limited to misfolded proteins. That stress response, termed "physiologic aggresome," is exemplified by aggresome formation of inducible nitric oxide synthase (iNOS), an important host defense protein. CHIP (car...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Detergents
Share to Dyneins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Inclusion Bodies

Share to Microtubules

Share to Nitric Oxide Synthase Type II

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 18955503
DOI: 10.1128/MCB.00829-08
PMCID: PMC2612489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18955503-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role for CHIP in the aggresome pathway.PMID 18955503Read ↗

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions.Semantic proximity Read ↗

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.Semantic proximity Read ↗

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.Semantic proximity Read ↗

The p97-UBXN1 complex regulates aggresome formationSemantic proximity Read ↗

p38δ MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stressSemantic proximity Read ↗

Dynamic profiling of the aggresome processing pathwaySemantic proximity Read ↗

C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.Semantic proximity Read ↗

Co-chaperone CHIP stabilizes aggregate-prone malin, a ubiquitin ligase mutated in Lafora disease.Semantic proximity Read ↗

Endoplasmic reticulum protein quality control is determined by cooperative interactions between Hsp/c70 protein and the CHIP E3 ligase.Semantic proximity Read ↗

Caveolin-1 is an aggresome-inducing protein.Semantic proximity Read ↗

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.Semantic proximity Read ↗

CHIP chaperones wild type p53 tumor suppressor protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.