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Article

CHIP chaperones wild type p53 tumor suppressor protein.

The Journal of biological chemistry - 28 Sept 2007

Tripathi Veenu, Ali Amjad, Bhat Rajiv, Pati Uttam

Abstract excerpt

Wild type p53 exists in a constant state of equilibrium between wild type and mutant conformation and undergoes conformational changes at elevated temperature. We have demonstrated that the co-chaperone CHIP (carboxyl terminus of Hsp70-interacting protein), which suppressed aggregation of several misfolded substrates and induced the proteasomal degradation of both wild type and mutant p53, physically interacts...

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Identifiers

PMID: 17666403
DOI: 10.1074/jbc.M703698200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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