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Article

C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination.

The Journal of biological chemistry - 29 Oct 2010

Clapp Kelly M, Peng Hwei-Ming, Morishima Yoshihiro, Lau Miranda, Walker Vyvyca J, Pratt William B, Osawa Yoichi

Abstract excerpt

It is established that suicide inactivation of neuronal nitric-oxide synthase (nNOS) by drugs and other xenobiotics leads to ubiquitination and proteasomal degradation of the enzyme. The exact mechanism is not known, although it is widely thought that the covalent alteration of the active site du...

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Identifiers

PMID: 20729196
DOI: 10.1074/jbc.M110.159178
PMCID: PMC2962462

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20729196-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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