Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions.

The FEBS journal - 1 Sept 2018

Maan Meenu, Pati Uttam

Abstract excerpt

Tumor suppressor protein p53 aggregates in the hypoxic core of solid tumors. C terminus of Hsc70-interacting protein (CHIP) displays chaperone as well as E3 ligase activities in both stabilizing and degrading wild-type and mutant p53. In this study, we have discovered that CHIP selectively degrades aggregating mutant p53 under both normal and hypoxic conditions. Silencing of CHIP alleviates degradation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to A549 Cells
Share to Autophagy
Share to HCT116 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia

Share to Protein Processing, Post-Translational

Share to Proteolysis

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Identifiers

PMID: 29953728
DOI: 10.1111/febs.14602

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHIP promotes autophagy-mediated degradation of aggregating mutant p53 in hypoxic conditions.PMID 29953728Read ↗

Chaperone-dependent stabilization and degradation of p53 mutants.Semantic proximity Read ↗

CHIP chaperones wild type p53 tumor suppressor protein.Semantic proximity Read ↗

Chaperoning of mutant p53 protein by wild-type p53 protein causes hypoxic tumor regression.Semantic proximity Read ↗

Anticancer Therapeutic Strategies Targeting p53 Aggregation.Semantic proximity Read ↗

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer CellsSemantic proximity Read ↗

Hsp70 acts as a fine-switch that controls E3 ligase CHIP-mediated TAp63 and ΔNp63 ubiquitination and degradationSemantic proximity Read ↗

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.Semantic proximity Read ↗

The E3 Ligase CHIP Mediates p21 Degradation to Maintain RadioresistanceSemantic proximity Read ↗

Molecular interplay between mutant p53 proteins and autophagy in cancer cells.Semantic proximity Read ↗

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.Semantic proximity Read ↗

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.Semantic proximity Read ↗

Treating p53 Mutant Aggregation-Associated CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.