Article

Dynamic profiling of the aggresome processing pathway

2025-10-31

Abstract excerpt

Cellular homeostasis is maintained by the efficient degradation of proteins by the 26S proteasome, a key component of the ubiquitin proteasome system. When the proteasome function is impaired due to cellular stress like mutations, chemicals or epigenetic stressors, there is accumulation of unfolded or misfolded, ubiquitinated proteins leading to cellular toxicity. Cells combat this rise in cellular toxicity by seq...

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Literature Corpus work: 77b1d51c-7f68-5ac2-b9b6-202946f18ce9
DOI: 10.1101/2025.10.30.684516

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