p38δ MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress

Abstract excerpt

Aggresome formation is a major strategy to enable cells to cope with proteasomal stress. Misfolded proteins are assembled into micro-aggregates and transported to the microtubule organizing center (MTOC) to form perinuclear aggresomes before their degradation through autophagy. So far, multiple factors have been identified as the activators of micro-aggregate formation, but much less is known about the regulatory...

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