Article
Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.
Experimental neurology - 1 Jan 2009
Dupuis Luc, Fergani Anissa, Braunstein Kerstin E, Eschbach Judith, Holl Nathalie, Rene Frédérique, Gonzalez De Aguilar Jose-Luis, Zoerner Björn, Schwalenstocker Birgit, Ludolph Albert C, Loeffler Jean-Philippe
Abstract excerpt
In neurons, cytoplasmic dynein functions as a molecular motor responsible for retrograde axonal transport. An impairment of axonal transport is thought to play a key role in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis, the most frequent motor neuron disease in the elderly. In this regard, previous studies described two heterozygous mouse strains bearing missense point...
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