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Article

Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.

PloS one - 4 Feb 2011

Courchesne Stephanie L, Pazyra-Murphy Maria F, Lee Daniel J, Segal Rosalind A

Abstract excerpt

Disruptions in axonal transport have been implicated in a wide range of neurodegenerative diseases. Cramping 1 (Cra1/+) and Legs at odd angles (Loa/+) mice, with hypomorphic mutations in the dynein heavy chain 1 gene, which encodes the ATPase of the retrograde motor protein dynein, were originally reported to exhibit late onset motor neuron disease. Subsequent, conflicting reports suggested that sensory neuron...

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Identifiers

PMID: 21346813
DOI: 10.1371/journal.pone.0016753
PMCID: PMC3035627

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