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Article

Severe dynein dysfunction in cholinergic neurons exacerbates ALS-like phenotypes in a new mouse model.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2025

Simoes Fabio A, Christoforidou Eleni, Cassel Raphaelle, Dupuis Luc, Hafezparast Majid

Abstract excerpt

Cytoplasmic dynein 1, a motor protein essential for retrograde axonal transport, is increasingly implicated in the pathogenesis of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). In this study, we developed a novel mouse model that combines the Legs at odd angles (Loa, F580Y) point mutation in the dynein heavy chain with a cholinergic neuron-specific knockout of the dynein heavy chain....

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Identifiers

PMID: 39428001
DOI: 10.1016/j.bbadis.2024.167540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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