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Article

Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

Neuron - 30 May 2002

LaMonte Bernadette H, Wallace Karen E, Holloway Beth A, Shelly Spencer S, Ascaño Jennifer, Tokito Mariko, Van Winkle Thomas, Howland David S, Holzbaur Erika L F

Abstract excerpt

To test the hypothesis that inhibition of axonal transport is sufficient to cause motor neuron degeneration such as that observed in amyotrophic lateral sclerosis (ALS), we engineered a targeted disruption of the dynein-dynactin complex in postnatal motor neurons of transgenic mice. Dynamitin ove...

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Identifiers

PMID: 12062019
DOI: 10.1016/s0896-6273(02)00696-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12062019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.PMID 12062019Read ↗

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