Mutations in dynein link motor neuron degeneration to defects in retrograde transport.

doi:10.1126/science.1083129

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Article

Mutations in dynein link motor neuron degeneration to defects in retrograde transport.

Science (New York, N.Y.) - 2 May 2003

Hafezparast Majid, Klocke Rainer, Ruhrberg Christiana, Marquardt Andreas, Ahmad-Annuar Azlina, Bowen Samantha, Lalli Giovanna, Witherden Abi S, Hummerich Holger, Nicholson Sharon, Morgan P Jeffrey, Oozageer Ravi, Priestley John V, Averill Sharon, King Von R, Ball Simon, Peters Jo, Toda Takashi, Yamamoto Ayumu, Hiraoka Yasushi, Augustin Martin, Korthaus Dirk, Wattler Sigrid, Wabnitz Philipp, Dickneite Carmen, Lampel Stefan, Boehme Florian, Peraus Gisela, Popp Andreas, Rudelius Martina, Schlegel Juergen, Fuchs Helmut, Hrabe de Angelis Martin, Schiavo Giampietro, Shima David T, Russ Andreas P, Stumm Gabriele, Martin Joanne E, Fisher Elizabeth M C

Abstract excerpt

Degenerative disorders of motor neurons include a range of progressive fatal diseases such as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal muscular atrophy (SMA). Although the causative genetic alterations are known for some cases, the molecular basis of...

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PMID: 12730604
DOI: 10.1126/science.1083129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12730604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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