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Article

Early abnormalities in sciatic nerve function and structure in a rat model of Charcot-Marie-Tooth type 1A disease.

Experimental neurology - 1 Nov 2004

Grandis Marina, Leandri Massimo, Vigo Tiziana, Cilli Michele, Sereda Michael W, Gherardi Gianfranco, Benedetti Luana, Mancardi Gianluigi, Abbruzzese Michele, Nave Klaus-Armin, Nobbio Lucilla, Schenone Angelo

Abstract excerpt

We investigated early peripheral nervous system impairment in PMP22-transgenic rats ("CMT rat"), an established animal model for Charcot-Marie-Tooth disease 1A, at postnatal day 30 (P30), when the clinical phenotype is not yet apparent. Hemizygous CMT1A rats and wildtype littermates were studied by means of behavioral examination, electrophysiology, molecular biology, and light microscopy analysis. Behavioral...

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Source

Identifiers

PMID: 15473994
DOI: 10.1016/j.expneurol.2004.07.008

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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