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Article

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death.

Proceedings of the National Academy of Sciences of the United States of America - 26 Aug 2008

Ilieva Hristelina S, Yamanaka Koji, Malkmus Shelle, Kakinohana Osamu, Yaksh Tony, Marsala Martin, Cleveland Don W

Abstract excerpt

Dominant mutations in cytoplasmic dynein (Loa or Cra) have been reported to provoke selective, age-dependent killing of motor neurons, while paradoxically slowing degeneration and death of motor neurons in one mouse model of an inherited form of ALS. Examination of Loa animals reveals no degeneration of large caliber alpha-motor neurons beyond an age-dependent loss (initiating only after 18 months) that was...

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Source

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Identifiers

PMID: 18719118
DOI: 10.1073/pnas.0805422105
PMCID: PMC2527957

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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