Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Dec 2007

Chen Xiang-Jun, Levedakou Eleni N, Millen Kathleen J, Wollmann Robert L, Soliven Betty, Popko Brian

Abstract excerpt

Mice heterozygous for the radiation-induced Sprawling (Swl) mutation display an early-onset sensory neuropathy with muscle spindle deficiency. The lack of an H reflex despite normal motor nerve function in the hindlimbs of these mutants strongly suggests defective proprioception. Immunohistochemical analyses reveal that proprioceptive sensory neurons are severely compromised in the lumbar dorsal root ganglia of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Collagen Type IV

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasmic Dyneins

Share to Dyneins

Share to Embryo, Mammalian

Share to Ganglia, Spinal

Share to Neural Conduction

Share to Psychomotor Performance

Source

Open in PubMed Open full text

Identifiers

PMID: 18160659
DOI: 10.1523/JNEUROSCI.4338-07.2007
PMCID: PMC6673431

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proprioceptive sensory neuropathy in mice with a mutation in the cytoplasmic Dynein heavy chain 1 gene.PMID 18160659Read ↗

Dync1h1 Mutation Causes Proprioceptive Sensory Neuron Loss and Impaired Retrograde Axonal Transport of Dorsal Root Ganglion Neurons.Semantic proximity Read ↗

Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.Semantic proximity Read ↗

Mutant dynein (Loa) triggers proprioceptive axon loss that extends survival only in the SOD1 ALS model with highest motor neuron death.Semantic proximity Read ↗

Cytoplasmic dynein could be key to understanding neurodegeneration.Semantic proximity Read ↗

A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing.Semantic proximity Read ↗

Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.Semantic proximity Read ↗

Patient-specific mutation of Dync1h1 in mice causes brain and behavioral deficits.Semantic proximity Read ↗

A dynein mutation attenuates motor neuron degeneration in SOD1(G93A) mice.Semantic proximity Read ↗

A human dynein heavy chain mutation impacts cortical progenitor cells causing developmental defects, reduced brain size and altered brain architecture.Semantic proximity Read ↗

Cytoplasmic dynein heavy chain: the servant of many masters.Semantic proximity Read ↗

Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions.Semantic proximity Read ↗

Muscle spindle alterations precede onset of sensorimotor deficits in Charcot-Marie-Tooth type 2E.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.