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Article

Positional cloning by fast-track SNP-mapping in Drosophila melanogaster.

Nature protocols - 1 Jan 2008

Schnorrer Frank, Ahlford Annika, Chen Doris, Milani Lili, Syvänen Ann-Christine

Abstract excerpt

Positional cloning of chemically induced mutations is the rate-limiting step in forward genetic screens in Drosophila. Single-nucleotide polymorphisms (SNPs) are useful markers to locate a mutated region in the genome. Here, we provide a protocol for high-throughput, high-resolution SNP mapping that enables rapid and cost-effective positional cloning in Drosophila. In stage 1 of the protocol, we use highly...

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Share to Cloning, Molecular
Share to Drosophila melanogaster
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Nucleic Acid Hybridization

Share to Oligonucleotide Array Sequence Analysis

Share to Recombination, Genetic

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Source

Identifiers

PMID: 18948975
DOI: 10.1038/nprot.2008.175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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