Article
Single-nucleotide polymorphism mapping.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006
Davis M Wayne, Hammarlund Marc
Abstract excerpt
Single-nucleotide polymorphism (SNP) mapping is the easiest and most reliable way to map genes in Caenorhabditis elegans. SNPs are extremely dense and usually have no associated phenotype, making them ideal markers for mapping. SNP mapping has three steps. First, recombinant mutant animals are generated over a polymorphic strain (usually CB4856) using standard genetic techniques. Second, the genotype of these...
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