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Article

Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7.

Nucleic acids research - 6 Apr 2018

Zouaz Amel, Fernando Céline, Perez Yannick, Sardet Claude, Julien Eric, Grimaud Charlotte

Abstract excerpt

Tight cell-cycle regulation of the histone H4-K20 methyltransferase PR-Set7 is essential for the maintenance of genome integrity. In mammals, this mainly involves the interaction of PR-Set7 with the replication factor PCNA, which triggers the degradation of the enzyme by the CRL4CDT2 E3 ubiquitin ligase. PR-Set7 is also targeted by the SCFβ-TRCP ligase, but the role of this additional regulatory pathway remains...

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Identifiers

PMID: 29373730
DOI: 10.1093/nar/gky034
PMCID: PMC5888314

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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