Article
Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.
PLoS biology - 1 Sept 2016
Alavi Maryam, Song Minmin, King Gracie L Andrews, Gillis Taylor, Propst Robert, Lamanuzzi Matthew, Bousum Adam, Miller Amanda, Allen Ryan, Kidd Thomas
Abstract excerpt
The Slit protein is a major midline repellent for central nervous system (CNS) axons. In vivo, Slit is proteolytically cleaved into N- and C-terminal fragments, but the biological significance of this is unknown. Analysis in the Drosophila ventral nerve cord of a slit allele (slit-UC) that cannot be cleaved revealed that midline repulsion is still present but longitudinal axon guidance is disrupted, particularly...
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