Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons.

doi:10.1016/s0896-6273(00)80153-1

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Article

Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons.

Neuron - 1 Aug 1996

Mitchell K J, Doyle J L, Serafini T, Kennedy T E, Tessier-Lavigne M, Goodman C S, Dickson B J

Abstract excerpt

Two tandem Netrin genes in Drosophila are expressed at the midline of the developing CNS and in different subsets of neurons, muscles, and epidermal patches. In embryos carrying a small deficiency that deletes both genes, CNS axon commissures are partially missing or thinner. This phenotype is re...

Topics

Animals
Axons
Base Sequence
Central Nervous System
Chromosome Mapping
Cloning, Molecular
Drosophila
Epidermis
Gene Expression Regulation, Developmental
Genetic Complementation Test
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Neurons

Muscles

Nerve Growth Factors

Netrin-1

Netrins

Neurites

Peripheral Nervous System

Source

Open in PubMed

Identifiers

PMID: 8780645
DOI: 10.1016/s0896-6273(00)80153-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8780645-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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