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Article

High-frequency haplotypes in the X chromosome locus TLR8 are associated with both CD and UC in females.

Inflammatory bowel diseases - 1 Mar 2009

Saruta Masayuki, Targan Stephan R, Mei Ling, Ippoliti Andrew F, Taylor Kent D, Rotter Jerome I

Abstract excerpt

BACKGROUND: TNF-alpha and IL-1 have been associated with mucosal inflammation in both Crohn's disease (CD) and ulcerative colitis (UC). Innate immune defects have been associated with CD, specifically CARD15/NOD2. Recently, Toll-like receptor 8 (TLR8) signaling has been shown to enhance generation of both cytokines. Interestingly, TLR8 is located on the X chromosome and inflammatory bowel disease (IBD) has been...

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Share to Chromosomes, Human, X
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Diseases, X-Linked

Share to Immunity, Innate

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Source

Open in PubMed Open full text

Identifiers

PMID: 18942751
DOI: 10.1002/ibd.20754
PMCID: PMC2643315

Genes

TLR8
NOD2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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