Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

doi:10.1016/j.ajhg.2008.03.016

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Article

Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

American journal of human genetics - 1 May 2008

Zhernakova Alexandra, Festen Eleanora M, Franke Lude, Trynka Gosia, van Diemen Cleo C, Monsuur Alienke J, Bevova Marianna, Nijmeijer Rian M, van 't Slot Ruben, Heijmans Roel, Boezen H Marike, van Heel David A, van Bodegraven Adriaan A, Stokkers Pieter C F, Wijmenga Cisca, Crusius J Bart A, Weersma Rinse K

Abstract excerpt

The two main phenotypes of inflammatory bowel disease (IBD)--Crohn's disease (CD) and ulcerative colitis (UC)--are chronic intestinal inflammatory disorders with a complex genetic background. Using a three-stage design, we performed a functional candidate-gene analysis of innate immune pathway in IBD. In phase I, we typed 354 SNPs from 85 innate immunity genes in 520 Dutch IBD patients (284 CD, 236 UC) and 808...

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Identifiers

PMID: 18439550
DOI: 10.1016/j.ajhg.2008.03.016
PMCID: PMC2427314

Genes

CARD9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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