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Article

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.

Inflammatory bowel diseases - 3 Oct 2023

Khrom Michelle, Li Dalin, Naito Takeo, Lee Ho-Su, Botwin Gregory J, Potdar Alka A, Boucher Gabrielle, Yang Shaohong, Mengesha Emebet, Dube Shishir, Song Kyuyoung, McGovern Dermot P B, Haritunians Talin

Abstract excerpt

BACKGROUND: Sex is an integral variable often overlooked in complex disease genetics. Differences between sexes have been reported in natural history, disease complications, and age of onset in inflammatory bowel disease (IBD). While association studies have identified >230 IBD loci, there have been a limited number of studies investigating sex differences underlying these genetic associations. METHODS: We report...

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Identifiers

PMID: 37262302
DOI: 10.1093/ibd/izad089
PMCID: PMC10547236

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