Article
Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging.
Nucleic acids research - 1 Nov 2008
Xiao Feng, Zhang Hui, Guo Peixuan
Abstract excerpt
Many nucleic acid-binding proteins and the AAA+ family form hexameric rings, but the mechanism of hexamer assembly is unclear. It is generally believed that the specificity in protein/RNA interaction relies on molecular contact through a surface charge or 3D structure matching via conformational capture or induced fit. The pRNA of bacteriophage phi29 DNA-packaging motor also forms a ring, but whether the pRNA...
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